HTLV1 Target gene Detail Information

> KCNK1 Gene Search Result

Gene Information

Gene Name	KCNK1
Gene ID	3775
Gene Full Name	potassium two pore domain channel subfamily K member 1
Gene Alias	DPK; HOHO; K2P1; KCNO1; TWIK1; K2p1.1; TWIK-1
Transcripts	ENSG00000135750
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Vesicles;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Predicted membrane proteins, Voltage-gated ion channels
Uniport_ID	O00180
HGNC ID	HGNC:6272
VEGA ID	OTTHUMG00000037923
OMIM ID	601745
String ID	9606.ENSP00000355580
Drugbank ID	BE0000154
PharmGKB ID	PA219

Target gene [KCNK1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6006593	chr1	55	3	8	66	View
6007460	chr1	55			55	View
6029260	chr1		1		1	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of KCNK1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
KCNK1 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of KCNK1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
KCNK1 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of KCNK1 expression and immune infiltrating cell level correlation result in HTLV1+ samples
KCNK1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).