HTLV1 Target gene Detail Information

> KCNJ12 Gene Search Result

Gene Information

Gene Name	KCNJ12
Gene ID	3768
Gene Full Name	potassium voltage-gated channel subfamily J member 12
Gene Alias	IRK2; hIRK; IRK-2; hIRK1; KCNJN1; Kir2.2; Kir2.2v; kcnj12x; hkir2.2x
Transcripts	ENSG00000184185
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Golgi apparatus;Cytosol;Nucleoplasm;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	FDA approved drug targets, Predicted membrane proteins, Voltage-gated ion channels
Uniport_ID	Q14500
HGNC ID	HGNC:6258
VEGA ID	OTTHUMG00000132039
OMIM ID	602323
String ID	9606.ENSP00000463778
Drugbank ID	BE0001131; BE0004905
PharmGKB ID	PA218

Target gene [KCNJ12] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6001110	chr17	569	9	1	579	View
6001111	chr17	569	9	1	579	View
6001112	chr17	569	9	1	579	View
6001113	chr17	569	9	1	579	View
6001114	chr17	569	9	1	579	View
6001115	chr17	569	9	1	579	View
6001116	chr17	569	9	1	579	View
6001117	chr17	569	9	1	579	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of KCNJ12 expression and immune infiltrating cell level correlation result in HTLV1+ samples
KCNJ12 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of KCNJ12 expression and immune infiltrating cell level correlation result in HTLV1+ samples
KCNJ12 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of KCNJ12 expression and immune infiltrating cell level correlation result in HTLV1+ samples
KCNJ12 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).