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HTLV1 Target gene Detail Information

> KCNC3 Gene Search Result


Gene Information
Gene Name KCNC3
Gene ID 3748
Gene Full Name potassium voltage-gated channel subfamily C member 3
Gene Alias KV3.3; SCA13; KSHIIID
Transcripts ENSG00000131398
Virus HTLV1
Gene Type protein coding
HPA Location Info
Membrane Info Predicted membrane proteins
HPA Protein Class Info Disease related genes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels
Uniport_ID Q14003
HGNC ID HGNC:6235
VEGA ID OTTHUMG00000044580
OMIM ID 176264
String ID 9606.ENSP00000434241
Drugbank ID BE0004725; BE0009847
PharmGKB ID PA30027
Target gene [KCNC3] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6006096 chr19 67 6 1 74 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of KCNC3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
KCNC3 expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of KCNC3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
KCNC3 expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of KCNC3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
KCNC3 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).