HTLV1 Target gene Detail Information

> KCNA4 Gene Search Result

Gene Information

Gene Name	KCNA4
Gene ID	3739
Gene Full Name	potassium voltage-gated channel subfamily A member 4
Gene Alias	HK1; HBK4; PCN2; HPCN2; HUKII; KCNA8; KV1.4; KCNA4L
Transcripts	ENSG00000182255
Virus	HTLV1
Gene Type	protein coding
HPA Location Info
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	FDA approved drug targets, Plasma proteins, Predicted membrane proteins, Voltage-gated ion channels
Uniport_ID	P22459
HGNC ID	HGNC:6222
VEGA ID	OTTHUMG00000166144
OMIM ID	176266
String ID	9606.ENSP00000328511
Drugbank ID	BE0004502; BE0009847
PharmGKB ID	PA207

Target gene [KCNA4] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6018756	chr11	7	2		9	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of KCNA4 expression and immune infiltrating cell level correlation result in HTLV1+ samples
KCNA4 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of KCNA4 expression and immune infiltrating cell level correlation result in HTLV1+ samples
KCNA4 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of KCNA4 expression and immune infiltrating cell level correlation result in HTLV1+ samples
KCNA4 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).