HPV Target gene Detail Information

> KAZN Gene Search Result

Gene Information

Gene Name	KAZN
Gene ID	23254
Gene Full Name	kazrin, periplakin interacting protein
Gene Alias	KAZ
Transcripts	ENSG00000189337
Virus	HPV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Cytosol;Nuclear speckles;
HPA Protein Class Info	Predicted intracellular proteins
Uniport_ID	Q674X7
HGNC ID	HGNC:29173
VEGA ID	OTTHUMG00000002042
OMIM ID	618301
String ID	9606.ENSP00000365198
PharmGKB ID	PA166048988

Target gene [KAZN] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
5004491	chr1				0	View
5200214	chr1	31	20	13	64	View
5400163	chr1	27	9	1	37	View
5400353	chr1	17			17	View
5402985	chr1	12	2		14	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE140662 (GEO)	Condyloma Acuminatum	8	Condyloma acuminata (HPV+)(5), Skin(3)
GSE40774 (GEO)	Head and neck squamous cell carcinoma	134	Head and neck Squamous cell carcinomas GLOTTIC LARYNX (EBV-)(2), Head and neck Squamous cell carcinomas HYPOPHARYNX (EBV-)(9), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV-)(23), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV+)(2), Head and neck Squamous cell carcinomas OROPHARYNX (EBV-)(22), Head and neck Squamous cell carcinomas OROPHARYNX (EBV+)(54), Head and neck Squamous cell carcinomas OTHER (EBV+)(1), Head and neck Squamous cell carcinomas SUBGLOTTIC LARYNX (EBV-)(1), Head and neck Squamous cell carcinomas SUPRAGLOTTIC (EBV-)(19), Squamous cell carcinomas SUPRAGLOTTIC (EBV+)(1)
GSE55546 (GEO)	Oropharyngeal squamous cell carcinoma	16	Oropharyngeal cancers (HPV+)(12), Normal (4)
GSE55544 (GEO)	Oropharyngeal squamous cell carcinoma	23	Oropharyngeal cancers HPV Active (11), Oropharyngeal cancers HPV Inactive (4), Oropharyngeal cancers HPV Negative (8)
GSE55542 (GEO)	Oropharyngeal squamous cell carcinoma	36	Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)

> Dataset: GSE140662
HeatMap of cell type fractions in all samples	Lollipop of KAZN expression and immune infiltrating cell level correlation result in HPV+ samples
KAZN expression: Low -> High

> Dataset: GSE40774
HeatMap of cell type fractions in all samples	Lollipop of KAZN expression and immune infiltrating cell level correlation result in HPV+ samples
KAZN expression: Low -> High

> Dataset: GSE55546
HeatMap of cell type fractions in all samples	Lollipop of KAZN expression and immune infiltrating cell level correlation result in HPV+ samples
KAZN expression: Low -> High

> Dataset: GSE55544
HeatMap of cell type fractions in all samples	Lollipop of KAZN expression and immune infiltrating cell level correlation result in HPV+ samples
KAZN expression: Low -> High

> Dataset: GSE55542
HeatMap of cell type fractions in all samples	Lollipop of KAZN expression and immune infiltrating cell level correlation result in HPV+ samples
KAZN expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).

> Dataset: GSE140662