HPV Target gene Detail Information

> JRKL Gene Search Result

Gene Information

Gene Name	JRKL
Gene ID	8690
Gene Full Name	JRK like
Gene Alias	HHMJG
Transcripts	ENSG00000183340
Virus	HPV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Cytokinetic bridge;
HPA Protein Class Info	Plasma proteins, Predicted intracellular proteins
Uniport_ID	Q9Y4A0
HGNC ID	HGNC:6200
VEGA ID	OTTHUMG00000154950
OMIM ID	603211
String ID	9606.ENSP00000333350
PharmGKB ID	PA30002

Target gene [JRKL] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
5402701	chr11	1		3	4	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE65858 (GEO)	Head and neck squamous cell carcinoma	270	Head and neck squamous cell carcinoma (EBV+)(73), Head and neck squamous cell carcinoma (EBV-)(197)
GSE40774 (GEO)	Head and neck squamous cell carcinoma	134	Head and neck Squamous cell carcinomas GLOTTIC LARYNX (EBV-)(2), Head and neck Squamous cell carcinomas HYPOPHARYNX (EBV-)(9), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV-)(23), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV+)(2), Head and neck Squamous cell carcinomas OROPHARYNX (EBV-)(22), Head and neck Squamous cell carcinomas OROPHARYNX (EBV+)(54), Head and neck Squamous cell carcinomas OTHER (EBV+)(1), Head and neck Squamous cell carcinomas SUBGLOTTIC LARYNX (EBV-)(1), Head and neck Squamous cell carcinomas SUPRAGLOTTIC (EBV-)(19), Squamous cell carcinomas SUPRAGLOTTIC (EBV+)(1)
GSE55542 (GEO)	Oropharyngeal squamous cell carcinoma	36	Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)
GSE138080 (GEO)	Cervical intraepithelial neoplasia	25	Normal (10), Cervical intraepithelial neoplasia (HPV+)(15)
GSE51993 (GEO)	Cervical intraepithelial neoplasia	24	Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA)	Head and Neck squamous cell carcinoma	566	Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE65858
HeatMap of cell type fractions in all samples	Lollipop of JRKL expression and immune infiltrating cell level correlation result in HPV+ samples
JRKL expression: Low -> High

> Dataset: GSE40774
HeatMap of cell type fractions in all samples	Lollipop of JRKL expression and immune infiltrating cell level correlation result in HPV+ samples
JRKL expression: Low -> High

> Dataset: GSE55542
HeatMap of cell type fractions in all samples	Lollipop of JRKL expression and immune infiltrating cell level correlation result in HPV+ samples
JRKL expression: Low -> High

> Dataset: GSE138080
HeatMap of cell type fractions in all samples	Lollipop of JRKL expression and immune infiltrating cell level correlation result in HPV+ samples
JRKL expression: Low -> High

> Dataset: GSE51993
HeatMap of cell type fractions in all samples	Lollipop of JRKL expression and immune infiltrating cell level correlation result in HPV+ samples
JRKL expression: Low -> High

> Dataset: HNSC
HeatMap of cell type fractions in all samples	Lollipop of JRKL expression and immune infiltrating cell level correlation result in HPV+ samples
JRKL expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).

> Dataset: GSE65858