HIV Target gene Detail Information

> JAK2 Gene Search Result

Gene Information

Gene Name	JAK2
Gene ID	3717
Gene Full Name	Janus kinase 2
Gene Alias	JTK10; THCYT3
Transcripts	ENSG00000096968
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Focal adhesion sites;Plasma membrane;
HPA Protein Class Info	Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins
Gene Function	Oncogene
Uniport_ID	O60674
HGNC ID	HGNC:6192
VEGA ID	OTTHUMG00000019490
OMIM ID	147796
String ID	9606.ENSP00000371067
Drugbank ID	BE0002408
PharmGKB ID	PA29989

Target gene [JAK2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4003557	chr9	16	43		59	View
4005582	chr9	31			31	View
4007094	chr9	1	20		21	View
4007156	chr9	21			21	View
4012367	chr9	3	2		5	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of JAK2 expression and immune infiltrating cell level correlation result in HIV+ samples
JAK2 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of JAK2 expression and immune infiltrating cell level correlation result in HIV+ samples
JAK2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).