HIV Target gene Detail Information

> ITPR3 Gene Search Result

Gene Information

Gene Name	ITPR3
Gene ID	3710
Gene Full Name	inositol 1,4,5-trisphosphate receptor type 3
Gene Alias	IP3R; IP3R3
Transcripts	ENSG00000096433
Virus	HIV
Gene Type	protein coding
HPA Location Info	Vesicles;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Plasma proteins, Predicted membrane proteins
Uniport_ID	Q14573
HGNC ID	HGNC:6182
VEGA ID	OTTHUMG00000014532
OMIM ID	147267
String ID	9606.ENSP00000363435
Drugbank ID	BE0004848; BE0004914
PharmGKB ID	PA29980

Target gene [ITPR3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4003500	chr6	50	10		60	View
4005955	chr6	19	8	1	28	View
4009002	chr6	13			13	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of ITPR3 expression and immune infiltrating cell level correlation result in HIV+ samples
ITPR3 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of ITPR3 expression and immune infiltrating cell level correlation result in HIV+ samples
ITPR3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).