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HIV Target gene Detail Information

> ITM2B Gene Search Result


Gene Information
Gene Name ITM2B
Gene ID 9445
Gene Full Name integral membrane protein 2B
Gene Alias BRI; FBD; ABRI; BRI2; E25B; E3-16; RDGCA; imBRI2; BRICD2B
Transcripts ENSG00000136156
Virus HIV
Gene Type protein coding
HPA Location Info Golgi apparatus;Vesicles;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Disease related genes, Predicted membrane proteins
Uniport_ID Q9Y287
HGNC ID HGNC:6174
VEGA ID OTTHUMG00000016894
OMIM ID 603904
String ID 9606.ENSP00000367828
PharmGKB ID PA29971
Target gene [ITM2B] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
4000850 chr13 140 93 32 265 View
4006112 chr13 26 1 27 View
4010556 chr13 3 5 8 View
4012056 chr13 1 2 2 5 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE17372 (GEO) AIDS-associated lymphoma 17 AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO) HIV-infected disease 44 HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372

HeatMap of cell type fractions in all samples Lollipop of ITM2B expression and immune infiltrating cell level correlation result in HIV+ samples
ITM2B expression: Low -> High

> Dataset: GSE50834

HeatMap of cell type fractions in all samples Lollipop of ITM2B expression and immune infiltrating cell level correlation result in HIV+ samples
ITM2B expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).