HPV Target gene Detail Information

> ITIH6 Gene Search Result

Gene Information

Gene Name	ITIH6
Gene ID	347365
Gene Full Name	inter-alpha-trypsin inhibitor heavy chain family member 6
Gene Alias	ITIH5L; UNQ6369; dJ14O9.1
Transcripts	ENSG00000102313
Virus	HPV
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Predicted secreted proteins
Uniport_ID	Q6UXX5
HGNC ID	HGNC:28907
VEGA ID	OTTHUMG00000021634
String ID	9606.ENSP00000218436
PharmGKB ID	PA134930661

Target gene [ITIH6] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
5201038	chrX	32	1	8	41	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE140662 (GEO)	Condyloma Acuminatum	8	Condyloma acuminata (HPV+)(5), Skin(3)
GSE55546 (GEO)	Oropharyngeal squamous cell carcinoma	16	Oropharyngeal cancers (HPV+)(12), Normal (4)
GSE55544 (GEO)	Oropharyngeal squamous cell carcinoma	23	Oropharyngeal cancers HPV Active (11), Oropharyngeal cancers HPV Inactive (4), Oropharyngeal cancers HPV Negative (8)
GSE55542 (GEO)	Oropharyngeal squamous cell carcinoma	36	Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)

> Dataset: GSE140662
HeatMap of cell type fractions in all samples	Lollipop of ITIH6 expression and immune infiltrating cell level correlation result in HPV+ samples
ITIH6 expression: Low -> High

> Dataset: GSE55546
HeatMap of cell type fractions in all samples	Lollipop of ITIH6 expression and immune infiltrating cell level correlation result in HPV+ samples
ITIH6 expression: Low -> High

> Dataset: GSE55544
HeatMap of cell type fractions in all samples	Lollipop of ITIH6 expression and immune infiltrating cell level correlation result in HPV+ samples
ITIH6 expression: Low -> High

> Dataset: GSE55542
HeatMap of cell type fractions in all samples	Lollipop of ITIH6 expression and immune infiltrating cell level correlation result in HPV+ samples
ITIH6 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).