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HBV Target gene Detail Information

> ITGB3 Gene Search Result


Gene Information
Gene Name ITGB3
Gene ID 3690
Gene Full Name integrin subunit beta 3
Gene Alias GT; CD61; GP3A; BDPLT2; GPIIIa; BDPLT16
Transcripts ENSG00000259207
Virus HBV
Gene Type protein coding
HPA Location Info Plasma membrane;Nucleoplasm;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Cancer-related genes, CD markers, Disease related genes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Gene Function Suppressor gene
Uniport_ID P05106
HGNC ID HGNC:6156
VEGA ID OTTHUMG00000171956
OMIM ID 173470
String ID 9606.ENSP00000452786
Drugbank ID BE0001155
Drug (Cytoscape Annotation) Paclitaxel
PharmGKB ID PA205
Target gene [ITGB3] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1001405 chr17 376 275 80 731 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of ITGB3 expression and immune infiltrating cell level correlation result in HBV+ samples
ITGB3 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).