HIV Target gene Detail Information

> ITGB1 Gene Search Result

Gene Information

Gene Name	ITGB1
Gene ID	3688
Gene Full Name	integrin subunit beta 1
Gene Alias	CD29; FNRB; MDF2; VLAB; GPIIA; MSK12; VLA-BETA
Transcripts	ENSG00000150093
Virus	HIV
Gene Type	protein coding
HPA Location Info	Focal adhesion sites;Plasma membrane;Endoplasmic reticulum;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Cancer-related genes, CD markers, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Gene Function	Suppressor gene
Uniport_ID	P05556
HGNC ID	HGNC:6153
VEGA ID	OTTHUMG00000017928
OMIM ID	135630
String ID	9606.ENSP00000379350
Drugbank ID	BE0003575
PharmGKB ID	PA29953

Target gene [ITGB1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4001565	chr10	48	80	22	150	View
4003176	chr10	8	57	2	67	View
4007390	chr10	14	5		19	View
4008217	chr10	9	7		16	View
4008322	chr10	5	9	1	15	View
4012851	chr10	3		1	4	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of ITGB1 expression and immune infiltrating cell level correlation result in HIV+ samples
ITGB1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of ITGB1 expression and immune infiltrating cell level correlation result in HIV+ samples
ITGB1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).