HIV Target gene Detail Information

> ITGA5 Gene Search Result

Gene Information

Gene Name	ITGA5
Gene ID	3678
Gene Full Name	integrin subunit alpha 5
Gene Alias	FNRA; CD49e; VLA-5; VLA5A
Transcripts	ENSG00000161638
Virus	HIV
Gene Type	protein coding
HPA Location Info
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Cancer-related genes, CD markers, Plasma proteins, Predicted membrane proteins
Gene Function	Suppressor gene
Uniport_ID	P08648
HGNC ID	HGNC:6141
VEGA ID	OTTHUMG00000169841
OMIM ID	135620
String ID	9606.ENSP00000293379
Drugbank ID	BE0008913
PharmGKB ID	PA29941

Target gene [ITGA5] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4013284	chr12	1	3		4	View
4013285	chr12	1	3		4	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of ITGA5 expression and immune infiltrating cell level correlation result in HIV+ samples
ITGA5 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of ITGA5 expression and immune infiltrating cell level correlation result in HIV+ samples
ITGA5 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).