HBV Target gene Detail Information

> IRF8 Gene Search Result

Gene Information

Gene Name	IRF8
Gene ID	3394
Gene Full Name	interferon regulatory factor 8
Gene Alias	ICSBP; IRF-8; ICSBP1; IMD32A; IMD32B; H-ICSBP
Transcripts	ENSG00000140968
Virus	HBV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
HPA Protein Class Info	Disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors
Gene Function	Suppressor gene
Uniport_ID	Q02556
HGNC ID	HGNC:5358
VEGA ID	OTTHUMG00000137648
OMIM ID	601565
String ID	9606.ENSP00000268638
PharmGKB ID	PA29606

Target gene [IRF8] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1006586	chr16	35	1		36	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of IRF8 expression and immune infiltrating cell level correlation result in HBV+ samples
IRF8 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).