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HPV Target gene Detail Information

> IRF4 Gene Search Result


Gene Information
Gene Name IRF4
Gene ID 3662
Gene Full Name interferon regulatory factor 4
Gene Alias MUM1; LSIRF; SHEP8; NF-EM5
Transcripts ENSG00000137265
Virus HPV
Gene Type protein coding
HPA Location Info Nucleoplasm;Cytosol;
HPA Protein Class Info Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors
Gene Function Suppressor gene & Oncogene
Uniport_ID Q15306
HGNC ID HGNC:6119
VEGA ID OTTHUMG00000016294
OMIM ID 601900
String ID 9606.ENSP00000370343
PharmGKB ID PA29918
Target gene [IRF4] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
5402829 chr6 135 98 92 325 View
5402837 chr6 109 89 90 288 View
5402838 chr6 136 99 90 325 View
5402839 chr6 136 99 90 325 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE65858 (GEO) Head and neck squamous cell carcinoma 270 Head and neck squamous cell carcinoma (EBV+)(73), Head and neck squamous cell carcinoma (EBV-)(197)
GSE55546 (GEO) Oropharyngeal squamous cell carcinoma 16 Oropharyngeal cancers (HPV+)(12), Normal (4)
GSE55544 (GEO) Oropharyngeal squamous cell carcinoma 23 Oropharyngeal cancers HPV Active (11), Oropharyngeal cancers HPV Inactive (4), Oropharyngeal cancers HPV Negative (8)
GSE55542 (GEO) Oropharyngeal squamous cell carcinoma 36 Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)
GSE51993 (GEO) Cervical intraepithelial neoplasia 24 Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA) Head and Neck squamous cell carcinoma 566 Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE65858

HeatMap of cell type fractions in all samples Lollipop of IRF4 expression and immune infiltrating cell level correlation result in HPV+ samples
IRF4 expression: Low -> High

> Dataset: GSE55546

HeatMap of cell type fractions in all samples Lollipop of IRF4 expression and immune infiltrating cell level correlation result in HPV+ samples
IRF4 expression: Low -> High

> Dataset: GSE55544

HeatMap of cell type fractions in all samples Lollipop of IRF4 expression and immune infiltrating cell level correlation result in HPV+ samples
IRF4 expression: Low -> High

> Dataset: GSE55542

HeatMap of cell type fractions in all samples Lollipop of IRF4 expression and immune infiltrating cell level correlation result in HPV+ samples
IRF4 expression: Low -> High

> Dataset: GSE51993

HeatMap of cell type fractions in all samples Lollipop of IRF4 expression and immune infiltrating cell level correlation result in HPV+ samples
IRF4 expression: Low -> High

> Dataset: HNSC

HeatMap of cell type fractions in all samples Lollipop of IRF4 expression and immune infiltrating cell level correlation result in HPV+ samples
IRF4 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).