HTLV1 Target gene Detail Information

> IRAK3 Gene Search Result


Gene Information
Gene Name IRAK3
Gene ID 11213
Gene Full Name interleukin 1 receptor associated kinase 3
Gene Alias ASRT5; IRAKM
Transcripts ENSG00000090376
Virus HTLV1
Gene Type protein coding
HPA Location Info Vesicles;
HPA Protein Class Info Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Uniport_ID Q9Y616
HGNC ID HGNC:17020
VEGA ID OTTHUMG00000169002
OMIM ID 604459
String ID 9606.ENSP00000261233
Drugbank ID BE0009407
PharmGKB ID PA38431
Target gene [IRAK3] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6000916 chr12 666 24 21 711 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of IRAK3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
IRAK3 expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of IRAK3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
IRAK3 expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of IRAK3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
IRAK3 expression: Low -> High

Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).