HBV Target gene Detail Information

> IQSEC3 Gene Search Result

Gene Information

Gene Name	IQSEC3
Gene ID	440073
Gene Full Name	IQ motif and Sec7 domain 3
Transcripts	ENSG00000262607
Virus	HBV
Gene Type	protein coding
HPA Location Info	Cytosol;Nucleoplasm;
HPA Protein Class Info	Predicted intracellular proteins
Uniport_ID	Q9UPP2
HGNC ID	HGNC:29193
VEGA ID	OTTHUMG00000174852
OMIM ID	612118
String ID	9606.ENSP00000437554
PharmGKB ID	PA134990290

Target gene [IQSEC3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1002084	chr12	67	256	28	351	View
1002091	chr12	67	254	27	348	View
1004848	chr12	46	15	6	67	View
1012956	chr12	6			6	View
1019999	chr12				0	View
1020000	chr12				0	View
1020008	chr12				0	View
1020013	chr12				0	View
1403251	chr12	46	15	6	67	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE114783 (GEO)	Chronic HBV (CHB) infection	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Hepatocellular carcinoma	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Liver cirrhosis	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783
HeatMap of cell type fractions in all samples	Lollipop of IQSEC3 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
IQSEC3 expression: Low -> High
Lollipop of IQSEC3 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples	Lollipop of IQSEC3 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples


> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of IQSEC3 expression and immune infiltrating cell level correlation result in HBV+ samples
IQSEC3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).