HBV Target gene Detail Information

> IQSEC2 Gene Search Result

Gene Information

Gene Name	IQSEC2
Gene ID	23096
Gene Full Name	IQ motif and Sec7 domain 2
Gene Alias	MRX1; BRAG1; MRX18; MRX78; IQ-ArfGEF
Transcripts	ENSG00000124313
Virus	HBV
Gene Type	protein coding
HPA Location Info	Lipid droplets;Vesicles;
HPA Protein Class Info	Disease related genes, Predicted intracellular proteins
Uniport_ID	Q5JU85
HGNC ID	HGNC:29059
VEGA ID	OTTHUMG00000021608
OMIM ID	300522
String ID	9606.ENSP00000379712
PharmGKB ID	PA134870898

Target gene [IQSEC2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1001672	chrX	17	326	190	533	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE114783 (GEO)	Chronic HBV (CHB) infection	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Hepatocellular carcinoma	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Liver cirrhosis	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783
HeatMap of cell type fractions in all samples	Lollipop of IQSEC2 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
IQSEC2 expression: Low -> High
Lollipop of IQSEC2 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples	Lollipop of IQSEC2 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples


> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of IQSEC2 expression and immune infiltrating cell level correlation result in HBV+ samples
IQSEC2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).