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HBV Target gene Detail Information

> IQSEC1 Gene Search Result


Gene Information
Gene Name IQSEC1
Gene ID 9922
Gene Full Name IQ motif and Sec7 domain 1
Gene Alias BRAG2; GEP100; ARFGEP100; ARF-GEP100
Transcripts ENSG00000144711
Virus HBV
Gene Type protein coding
HPA Location Info Nucleoli;Nucleoli rim;Vesicles;
HPA Protein Class Info Predicted intracellular proteins
Uniport_ID Q6DN90
HGNC ID HGNC:29112
VEGA ID OTTHUMG00000155398
OMIM ID 610166
String ID 9606.ENSP00000480301
PharmGKB ID PA128394566
Target gene [IQSEC1] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1002070 chr3 11 113 231 355 View
1009953 chr3 11 3 14 View
1011174 chr3 10 10 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of IQSEC1 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
IQSEC1 expression: Low -> High
Lollipop of IQSEC1 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of IQSEC1 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of IQSEC1 expression and immune infiltrating cell level correlation result in HBV+ samples
IQSEC1 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).