HIV Target gene Detail Information

> IQGAP1 Gene Search Result

Gene Information

Gene Name	IQGAP1
Gene ID	8826
Gene Full Name	IQ motif containing GTPase activating protein 1
Gene Alias	SAR1; p195; HUMORFA01
Transcripts	ENSG00000140575
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cell Junctions;Plasma membrane;
HPA Protein Class Info	Plasma proteins, Predicted intracellular proteins
Uniport_ID	P46940
HGNC ID	HGNC:6110
VEGA ID	OTTHUMG00000149832
OMIM ID	603379
String ID	9606.ENSP00000268182
Drugbank ID	BE0009027
PharmGKB ID	PA29910

Target gene [IQGAP1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000099	chr15	1010	56	43	1109	View
4000354	chr15	172	177	172	521	View
4001076	chr15	38	181		219	View
4002202	chr15	102	2	2	106	View
4002735	chr15	81	1		82	View
4003853	chr15	49	4		53	View
4004419	chr15	2	17	25	44	View
4005331	chr15	13	19	3	35	View
4005691	chr15	28	2		30	View
4005841	chr15	27	2		29	View
4008369	chr15	14		1	15	View
4008898	chr15	12	1		13	View
4009017	chr15	9	1	3	13	View
4009649	chr15	10	1		11	View
4011053	chr15	6		1	7	View
4013094	chr15	3	1		4	View
4016228	chr15				0	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of IQGAP1 expression and immune infiltrating cell level correlation result in HIV+ samples
IQGAP1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of IQGAP1 expression and immune infiltrating cell level correlation result in HIV+ samples
IQGAP1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).