HIV Target gene Detail Information

> INTS8 Gene Search Result

Gene Information

Gene Name	INTS8
Gene ID	55656
Gene Full Name	integrator complex subunit 8
Gene Alias	INT8; C8orf52
Transcripts	ENSG00000164941
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
HPA Protein Class Info	Predicted intracellular proteins
Gene Function	Oncogene
Uniport_ID	Q75QN2
HGNC ID	HGNC:26048
VEGA ID	OTTHUMG00000164695
OMIM ID	611351
String ID	9606.ENSP00000430338
PharmGKB ID	PA142672371

Target gene [INTS8] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4004764	chr8	35	5		40	View
4011115	chr8		7		7	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of INTS8 expression and immune infiltrating cell level correlation result in HIV+ samples
INTS8 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of INTS8 expression and immune infiltrating cell level correlation result in HIV+ samples
INTS8 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).