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HPV Target gene Detail Information

> INPPL1 Gene Search Result


Gene Information
Gene Name INPPL1
Gene ID 3636
Gene Full Name inositol polyphosphate phosphatase like 1
Gene Alias OPSMD; SHIP2
Transcripts ENSG00000165458
Virus HPV
Gene Type protein coding
HPA Location Info Cytosol;Golgi apparatus;
HPA Protein Class Info Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Gene Function Oncogene
Uniport_ID O15357
HGNC ID HGNC:6080
VEGA ID OTTHUMG00000167879
OMIM ID 600829
String ID 9606.ENSP00000298229
PharmGKB ID PA29888
Target gene [INPPL1] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
5402818 chr11 2 1 3 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE65858 (GEO) Head and neck squamous cell carcinoma 270 Head and neck squamous cell carcinoma (EBV+)(73), Head and neck squamous cell carcinoma (EBV-)(197)
GSE40774 (GEO) Head and neck squamous cell carcinoma 134 Head and neck Squamous cell carcinomas GLOTTIC LARYNX (EBV-)(2), Head and neck Squamous cell carcinomas HYPOPHARYNX (EBV-)(9), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV-)(23), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV+)(2), Head and neck Squamous cell carcinomas OROPHARYNX (EBV-)(22), Head and neck Squamous cell carcinomas OROPHARYNX (EBV+)(54), Head and neck Squamous cell carcinomas OTHER (EBV+)(1), Head and neck Squamous cell carcinomas SUBGLOTTIC LARYNX (EBV-)(1), Head and neck Squamous cell carcinomas SUPRAGLOTTIC (EBV-)(19), Squamous cell carcinomas SUPRAGLOTTIC (EBV+)(1)
GSE55546 (GEO) Oropharyngeal squamous cell carcinoma 16 Oropharyngeal cancers (HPV+)(12), Normal (4)
GSE55542 (GEO) Oropharyngeal squamous cell carcinoma 36 Oropharyngeal cancers HPV Active (12), Oropharyngeal cancers HPV Inactive (8), Oropharyngeal cancers HPV Negative (16)
GSE138080 (GEO) Cervical intraepithelial neoplasia 25 Normal (10), Cervical intraepithelial neoplasia (HPV+)(15)
GSE51993 (GEO) Cervical intraepithelial neoplasia 24 Cervical intraepithelial neoplasia (HPV+)(17), Normal(7)
HNSC (TCGA) Head and Neck squamous cell carcinoma 566 Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE65858

HeatMap of cell type fractions in all samples Lollipop of INPPL1 expression and immune infiltrating cell level correlation result in HPV+ samples
INPPL1 expression: Low -> High

> Dataset: GSE40774

HeatMap of cell type fractions in all samples Lollipop of INPPL1 expression and immune infiltrating cell level correlation result in HPV+ samples
INPPL1 expression: Low -> High

> Dataset: GSE55546

HeatMap of cell type fractions in all samples Lollipop of INPPL1 expression and immune infiltrating cell level correlation result in HPV+ samples
INPPL1 expression: Low -> High

> Dataset: GSE55542

HeatMap of cell type fractions in all samples Lollipop of INPPL1 expression and immune infiltrating cell level correlation result in HPV+ samples
INPPL1 expression: Low -> High

> Dataset: GSE138080

HeatMap of cell type fractions in all samples Lollipop of INPPL1 expression and immune infiltrating cell level correlation result in HPV+ samples
INPPL1 expression: Low -> High

> Dataset: GSE51993

HeatMap of cell type fractions in all samples Lollipop of INPPL1 expression and immune infiltrating cell level correlation result in HPV+ samples
INPPL1 expression: Low -> High

> Dataset: HNSC

HeatMap of cell type fractions in all samples Lollipop of INPPL1 expression and immune infiltrating cell level correlation result in HPV+ samples
INPPL1 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).