HIV Target gene Detail Information

> IL6ST Gene Search Result

Gene Information

Gene Name	IL6ST
Gene ID	3572
Gene Full Name	interleukin 6 signal transducer
Gene Alias	CD130; GP130; CDW130; IL-6RB
Transcripts	ENSG00000134352
Virus	HIV
Gene Type	protein coding
HPA Location Info	Plasma membrane;Golgi apparatus;Predicted to be secreted;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Cancer-related genes, Candidate cardiovascular disease genes, CD markers, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins
Uniport_ID	P40189
HGNC ID	HGNC:6021
VEGA ID	OTTHUMG00000097043
OMIM ID	600694
String ID	9606.ENSP00000370698
PharmGKB ID	PA29837

Target gene [IL6ST] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4006032	chr5	19	8		27	View
4006253	chr5	3	18	5	26	View
4008555	chr5	15			15	View
4011262	chr5	3	4		7	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of IL6ST expression and immune infiltrating cell level correlation result in HIV+ samples
IL6ST expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).