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HBV Target gene Detail Information

> IL6 Gene Search Result


Gene Information
Gene Name IL6
Gene ID 3569
Gene Full Name interleukin 6
Gene Alias CDF; HGF; HSF; BSF2; IL-6; BSF-2; IFNB2; IFN-beta-2
Transcripts ENSG00000136244
Virus HBV
Gene Type protein coding
HPA Location Info Vesicles;Predicted to be secreted;
HPA Protein Class Info Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Uniport_ID P05231
HGNC ID HGNC:6018
VEGA ID OTTHUMG00000023178
OMIM ID 147620
String ID 9606.ENSP00000385675
Drugbank ID BE0000918
PharmGKB ID PA198
Target gene [IL6] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1003896 chr7 14 78 11 103 View
1010315 chr6 6 2 4 12 View
1403858 chr6 6 2 4 12 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of IL6 expression and immune infiltrating cell level correlation result in HBV+ samples
IL6 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).