HIV Target gene Detail Information

> IL2RB Gene Search Result

Gene Information

Gene Name	IL2RB
Gene ID	3560
Gene Full Name	interleukin 2 receptor subunit beta
Gene Alias	CD122; IL15RB; P70-75
Transcripts	ENSG00000100385
Virus	HIV
Gene Type	protein coding
HPA Location Info
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Cancer-related genes, CD markers, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Uniport_ID	P14784
HGNC ID	HGNC:6009
VEGA ID	OTTHUMG00000150534
OMIM ID	146710
String ID	9606.ENSP00000216223
Drugbank ID	BE0000651
PharmGKB ID	PA29829

Target gene [IL2RB] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4001887	chr22	64	39	25	128	View
4003838	chr22	14	28	11	53	View
4004876	chr22	32	3	3	38	View
4005008	chr22	36		1	37	View
4016310	chr22				0	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of IL2RB expression and immune infiltrating cell level correlation result in HIV+ samples
IL2RB expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of IL2RB expression and immune infiltrating cell level correlation result in HIV+ samples
IL2RB expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).