HIV Target gene Detail Information

> IL21R Gene Search Result

Gene Information

Gene Name	IL21R
Gene ID	50615
Gene Full Name	interleukin 21 receptor
Gene Alias	NILR; CD360; IMD56
Transcripts	ENSG00000103522
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Plasma membrane;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Cancer-related genes, CD markers, Disease related genes, Predicted membrane proteins
Uniport_ID	Q9HBE5
HGNC ID	HGNC:6006
VEGA ID	OTTHUMG00000131675
OMIM ID	605383
String ID	9606.ENSP00000338010
PharmGKB ID	PA29821

Target gene [IL21R] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000832	chr16	73	180	16	269	View
4004960	chr16	37			37	View
4005453	chr16	32			32	View
4006329	chr16	24	1		25	View
4006986	chr16	21			21	View
4007606	chr16	18			18	View
4014701	chr16	2			2	View
4015911	chr16				0	View
4016236	chr16				0	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of IL21R expression and immune infiltrating cell level correlation result in HIV+ samples
IL21R expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of IL21R expression and immune infiltrating cell level correlation result in HIV+ samples
IL21R expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).