HTLV1 Target gene Detail Information

> IL15 Gene Search Result

Gene Information

Gene Name	IL15
Gene ID	3600
Gene Full Name	interleukin 15
Gene Alias	IL-15
Transcripts	ENSG00000164136
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Nuclear speckles;Nucleoplasm;Predicted to be secreted;
HPA Protein Class Info	Cancer-related genes, Predicted intracellular proteins, Predicted secreted proteins
Uniport_ID	P40933
HGNC ID	HGNC:5977
VEGA ID	OTTHUMG00000133418
OMIM ID	600554
String ID	9606.ENSP00000296545
Drugbank ID	BE0003486
PharmGKB ID	PA29790

Target gene [IL15] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6100036	chr4	4	1	2	7	View
6100037	chr4	16	5		21	View
6100038	chr4	75	4		79	View
6100039	chr4	19	24	1	44	View
6100040	chr4	16	10	28	54	View
6100041	chr4	13	3		16	View
6100042	chr4		1		1	View
6100043	chr4	6			6	View
6100044	chr4	11	2		13	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of IL15 expression and immune infiltrating cell level correlation result in HTLV1+ samples
IL15 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of IL15 expression and immune infiltrating cell level correlation result in HTLV1+ samples
IL15 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of IL15 expression and immune infiltrating cell level correlation result in HTLV1+ samples
IL15 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).