HIV Target gene Detail Information

> IL12RB1 Gene Search Result

Gene Information

Gene Name	IL12RB1
Gene ID	3594
Gene Full Name	interleukin 12 receptor subunit beta 1
Gene Alias	CD212; IMD30; IL12RB; IL-12R-BETA1
Transcripts	ENSG00000096996
Virus	HIV
Gene Type	protein coding
HPA Location Info	Plasma membrane;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	CD markers, Disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	P42701
HGNC ID	HGNC:5971
VEGA ID	OTTHUMG00000183417
OMIM ID	601604
String ID	9606.ENSP00000470788
PharmGKB ID	PA29786

Target gene [IL12RB1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000645	chr19	6	146	182	334	View
4002693	chr19	57	21	5	83	View
4003235	chr19	29	23	14	66	View
4005274	chr19	10	24		34	View
4007351	chr19	14	6		20	View
4011139	chr19	5	2		7	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of IL12RB1 expression and immune infiltrating cell level correlation result in HIV+ samples
IL12RB1 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of IL12RB1 expression and immune infiltrating cell level correlation result in HIV+ samples
IL12RB1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).