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HBV Target gene Detail Information

> IKZF1 Gene Search Result


Gene Information
Gene Name IKZF1
Gene ID 10320
Gene Full Name IKAROS family zinc finger 1
Gene Alias IK1; LYF1; LyF-1; CVID13; IKAROS; PPP1R92; PRO0758; ZNFN1A1; Hs.54452
Transcripts ENSG00000185811
Virus HBV
Gene Type protein coding
HPA Location Info Nucleoplasm;Cytosol;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Cancer-related genes, Disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transcription factors
Gene Function Suppressor gene & Oncogene
Uniport_ID Q13422
HGNC ID HGNC:13176
VEGA ID OTTHUMG00000155907
OMIM ID 603023
String ID 9606.ENSP00000331614
PharmGKB ID PA37748
Target gene [IKZF1] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1005916 chr7 17 15 14 46 View
1007574 chr7 18 5 3 26 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of IKZF1 expression and immune infiltrating cell level correlation result in HBV+ samples
IKZF1 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).