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HPV Target gene Detail Information

> IGSF3 Gene Search Result


Gene Information
Gene Name IGSF3
Gene ID 3321
Gene Full Name immunoglobulin superfamily member 3
Gene Alias V8; LCDD; EWI-3
Transcripts ENSG00000143061
Virus HPV
Gene Type protein coding
HPA Location Info Nucleoplasm;Cytosol;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID O75054
HGNC ID HGNC:5950
VEGA ID OTTHUMG00000022751
OMIM ID 603491
String ID 9606.ENSP00000358495
PharmGKB ID PA29763
Target gene [IGSF3] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
5400110 chr1 44 1 45 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE40774 (GEO) Head and neck squamous cell carcinoma 134 Head and neck Squamous cell carcinomas GLOTTIC LARYNX (EBV-)(2), Head and neck Squamous cell carcinomas HYPOPHARYNX (EBV-)(9), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV-)(23), Head and neck Squamous cell carcinomas ORAL CAVITY (EBV+)(2), Head and neck Squamous cell carcinomas OROPHARYNX (EBV-)(22), Head and neck Squamous cell carcinomas OROPHARYNX (EBV+)(54), Head and neck Squamous cell carcinomas OTHER (EBV+)(1), Head and neck Squamous cell carcinomas SUBGLOTTIC LARYNX (EBV-)(1), Head and neck Squamous cell carcinomas SUPRAGLOTTIC (EBV-)(19), Squamous cell carcinomas SUPRAGLOTTIC (EBV+)(1)
GSE138080 (GEO) Cervical intraepithelial neoplasia 25 Normal (10), Cervical intraepithelial neoplasia (HPV+)(15)
HNSC (TCGA) Head and Neck squamous cell carcinoma 566 Head and Neck squamous cell carcinoma(HPV-)(483),Head and Neck squamous cell carcinoma(HPV+)(39),Paracancerous(HPV-)(44)

> Dataset: GSE40774

HeatMap of cell type fractions in all samples Lollipop of IGSF3 expression and immune infiltrating cell level correlation result in HPV+ samples
IGSF3 expression: Low -> High

> Dataset: GSE138080

HeatMap of cell type fractions in all samples Lollipop of IGSF3 expression and immune infiltrating cell level correlation result in HPV+ samples
IGSF3 expression: Low -> High

> Dataset: HNSC

HeatMap of cell type fractions in all samples Lollipop of IGSF3 expression and immune infiltrating cell level correlation result in HPV+ samples
IGSF3 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).