HBV Target gene Detail Information

> IGF1 Gene Search Result

Gene Information

Gene Name	IGF1
Gene ID	3479
Gene Full Name	insulin like growth factor 1
Gene Alias	IGF; MGF; IGFI; IGF-I
Transcripts	ENSG00000017427
Virus	HBV
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Disease related genes, Plasma proteins, Predicted secreted proteins, RAS pathway related proteins
Gene Function	Suppressor gene
Uniport_ID	P05019
HGNC ID	HGNC:5464
VEGA ID	OTTHUMG00000149910
OMIM ID	147440
String ID	9606.ENSP00000302665
Drugbank ID	BE0003418
PharmGKB ID	PA29697

Target gene [IGF1] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1014739	chr12		3		3	View
1015599	chr12		2		2	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE114783 (GEO)	Chronic HBV (CHB) infection	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Hepatocellular carcinoma	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Liver cirrhosis	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783
HeatMap of cell type fractions in all samples	Lollipop of IGF1 expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
IGF1 expression: Low -> High
Lollipop of IGF1 expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples	Lollipop of IGF1 expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples


> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of IGF1 expression and immune infiltrating cell level correlation result in HBV+ samples
IGF1 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).