HIV Target gene Detail Information

> IFNAR2 Gene Search Result


Gene Information
Gene Name IFNAR2
Gene ID 3455
Gene Full Name interferon alpha and beta receptor subunit 2
Gene Alias IFN-R; IMD45; IFNABR; IFNARB; IFN-alpha-REC
Transcripts ENSG00000159110
Virus HIV
Gene Type protein coding
HPA Location Info
Membrane Info Predicted membrane proteins
HPA Protein Class Info Cancer-related genes, Disease related genes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins
Uniport_ID P48551
HGNC ID HGNC:5433
VEGA ID OTTHUMG00000065127
OMIM ID 602376
String ID 9606.ENSP00000343957
Drugbank ID BE0000385
PharmGKB ID PA29671
Target gene [IFNAR2] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
4003228 chr21 46 19 1 66 View
4004203 chr21 17 24 7 48 View
4011323 chr21 2 5 7 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE17372 (GEO) AIDS-associated lymphoma 17 AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO) HIV-infected disease 44 HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372

HeatMap of cell type fractions in all samples Lollipop of IFNAR2 expression and immune infiltrating cell level correlation result in HIV+ samples
IFNAR2 expression: Low -> High

> Dataset: GSE50834

HeatMap of cell type fractions in all samples Lollipop of IFNAR2 expression and immune infiltrating cell level correlation result in HIV+ samples
IFNAR2 expression: Low -> High

Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).