HIV Target gene Detail Information

> IFNAR2 Gene Search Result

Gene Information

Gene Name	IFNAR2
Gene ID	3455
Gene Full Name	interferon alpha and beta receptor subunit 2
Gene Alias	IFN-R; IMD45; IFNABR; IFNARB; IFN-alpha-REC
Transcripts	ENSG00000159110
Virus	HIV
Gene Type	protein coding
HPA Location Info
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Cancer-related genes, Disease related genes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins
Uniport_ID	P48551
HGNC ID	HGNC:5433
VEGA ID	OTTHUMG00000065127
OMIM ID	602376
String ID	9606.ENSP00000343957
Drugbank ID	BE0000385
PharmGKB ID	PA29671

Target gene [IFNAR2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4003228	chr21	46	19	1	66	View
4004203	chr21	17	24	7	48	View
4011323	chr21		2	5	7	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of IFNAR2 expression and immune infiltrating cell level correlation result in HIV+ samples
IFNAR2 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of IFNAR2 expression and immune infiltrating cell level correlation result in HIV+ samples
IFNAR2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).