HIV Target gene Detail Information

> IFI16 Gene Search Result

Gene Information

Gene Name	IFI16
Gene ID	3428
Gene Full Name	interferon gamma inducible protein 16
Gene Alias	PYHIN2; IFNGIP1
Transcripts	ENSG00000163565
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoli;Nucleoplasm;Cytosol;
HPA Protein Class Info	Plasma proteins, Predicted intracellular proteins
Gene Function	Suppressor gene
Uniport_ID	Q16666
HGNC ID	HGNC:5395
VEGA ID	OTTHUMG00000037108
OMIM ID	147586
String ID	9606.ENSP00000357113
PharmGKB ID	PA29642

Target gene [IFI16] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4002996	chr1	63	8		71	View
4015877	chr1				0	View
4015878	chr1				0	View
4015879	chr1				0	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of IFI16 expression and immune infiltrating cell level correlation result in HIV+ samples
IFI16 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of IFI16 expression and immune infiltrating cell level correlation result in HIV+ samples
IFI16 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).