HTLV1 Target gene Detail Information

> IDH3B Gene Search Result

Gene Information

Gene Name	IDH3B
Gene ID	3420
Gene Full Name	isocitrate dehydrogenase 3 (NAD(+)) beta
Gene Alias	RP46
Transcripts	ENSG00000101365
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Mitochondria;
HPA Protein Class Info	Citric acid cycle related proteins, Disease related genes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	O43837
HGNC ID	HGNC:5385
VEGA ID	OTTHUMG00000031699
OMIM ID	604526
String ID	9606.ENSP00000370223
Drugbank ID	BE0000559
PharmGKB ID	PA29633

Target gene [IDH3B] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6016433	chr20	12			12	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of IDH3B expression and immune infiltrating cell level correlation result in HTLV1+ samples
IDH3B expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of IDH3B expression and immune infiltrating cell level correlation result in HTLV1+ samples
IDH3B expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of IDH3B expression and immune infiltrating cell level correlation result in HTLV1+ samples
IDH3B expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).