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HBV Target gene Detail Information

> IDH3A Gene Search Result


Gene Information
Gene Name IDH3A
Gene ID 3419
Gene Full Name isocitrate dehydrogenase 3 (NAD(+)) alpha
Transcripts ENSG00000166411
Virus HBV
Gene Type protein coding
HPA Location Info Mitochondria;
HPA Protein Class Info Citric acid cycle related proteins, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins
Uniport_ID P50213
HGNC ID HGNC:5384
VEGA ID OTTHUMG00000143732
OMIM ID 601149
String ID 9606.ENSP00000299518
Drugbank ID BE0000011
PharmGKB ID PA29632
Target gene [IDH3A] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1012543 chr15 4 2 6 View
1402568 chr15 4 2 6 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE114783 (GEO) Chronic HBV (CHB) infection 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Hepatocellular carcinoma 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO) Liver cirrhosis 36 Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783

HeatMap of cell type fractions in all samples Lollipop of IDH3A expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
IDH3A expression: Low -> High
Lollipop of IDH3A expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples Lollipop of IDH3A expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of IDH3A expression and immune infiltrating cell level correlation result in HBV+ samples
IDH3A expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).