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HBV Target gene Detail Information

> IDH2 Gene Search Result


Gene Information
Gene Name IDH2
Gene ID 3418
Gene Full Name isocitrate dehydrogenase (NADP(+)) 2, mitochondrial
Gene Alias IDH; IDP; IDHM; IDPM; ICD-M; D2HGA2; mNADP-IDH
Transcripts ENSG00000182054
Virus HBV
Gene Type protein coding
HPA Location Info Mitochondria;
HPA Protein Class Info Cancer-related genes, Citric acid cycle related proteins, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins
Uniport_ID P48735
HGNC ID HGNC:5383
VEGA ID OTTHUMG00000149815
OMIM ID 147650
String ID 9606.ENSP00000331897
Drugbank ID BE0004527
PharmGKB ID PA29631
FDA Approved Drug Enasidenib;Venetoclax
Target gene [IDH2] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
1400028 chr15 51 5 56 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of IDH2 expression and immune infiltrating cell level correlation result in HBV+ samples
IDH2 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).