HTLV1 Target gene Detail Information

> ICOSLG Gene Search Result

Gene Information

Gene Name	ICOSLG
Gene ID	23308
Gene Full Name	inducible T cell costimulator ligand
Gene Alias	B7H2; GL50; B7-H2; B7RP1; CD275; ICOSL; LICOS; B7RP-1; ICOS-L
Transcripts	ENSG00000160223
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Cytoplasmic bodies;Plasma membrane;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	CD markers, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	O75144
HGNC ID	HGNC:17087
VEGA ID	OTTHUMG00000086920
OMIM ID	605717
PharmGKB ID	PA134977297

Target gene [ICOSLG] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6010510	chr21	28	2		30	View
6016388	chr21	12			12	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of ICOSLG expression and immune infiltrating cell level correlation result in HTLV1+ samples
ICOSLG expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of ICOSLG expression and immune infiltrating cell level correlation result in HTLV1+ samples
ICOSLG expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of ICOSLG expression and immune infiltrating cell level correlation result in HTLV1+ samples
ICOSLG expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).