HIV Target gene Detail Information

> ICOS Gene Search Result

Gene Information

Gene Name	ICOS
Gene ID	29851
Gene Full Name	inducible T cell costimulator
Gene Alias	AILIM; CD278; CVID1
Transcripts	ENSG00000163600
Virus	HIV
Gene Type	protein coding
HPA Location Info	Plasma membrane;Actin filaments;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	CD markers, Disease related genes, Predicted membrane proteins
Uniport_ID	Q9Y6W8
HGNC ID	HGNC:5351
VEGA ID	OTTHUMG00000132880
OMIM ID	604558
String ID	9606.ENSP00000319476
PharmGKB ID	PA29599

Target gene [ICOS] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4003626	chr2	55	2		57	View
4004222	chr2	46	1		47	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of ICOS expression and immune infiltrating cell level correlation result in HIV+ samples
ICOS expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of ICOS expression and immune infiltrating cell level correlation result in HIV+ samples
ICOS expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).