HIV Target gene Detail Information

> HTT Gene Search Result

Gene Information

Gene Name	HTT
Gene ID	3064
Gene Full Name	huntingtin
Gene Alias	HD; IT15; LOMARS
Transcripts	ENSG00000197386
Virus	HIV
Gene Type	protein coding
HPA Location Info	Nucleoplasm;Cytosol;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	P42858
HGNC ID	HGNC:4851
VEGA ID	OTTHUMG00000159916
OMIM ID	613004
String ID	9606.ENSP00000347184
Drugbank ID	BE0008920
PharmGKB ID	PA164741646

Target gene [HTT] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000299	chr4	124	166	281	571	View
4005953	chr4	6	12	10	28	View
4007680	chr4	10		8	18	View
4009578	chr4	11			11	View
4010432	chr4	6	2	1	9	View
4011255	chr4	7			7	View
4100032	chr4	85	12	15	112	View
4300089	chr4	31	2		33	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of HTT expression and immune infiltrating cell level correlation result in HIV+ samples
HTT expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of HTT expression and immune infiltrating cell level correlation result in HIV+ samples
HTT expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).