HIV Target gene Detail Information

> HTT Gene Search Result


Gene Information
Gene Name HTT
Gene ID 3064
Gene Full Name huntingtin
Gene Alias HD; IT15; LOMARS
Transcripts ENSG00000197386
Virus HIV
Gene Type protein coding
HPA Location Info Nucleoplasm;Cytosol;
Membrane Info Predicted membrane proteins
HPA Protein Class Info Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID P42858
HGNC ID HGNC:4851
VEGA ID OTTHUMG00000159916
OMIM ID 613004
String ID 9606.ENSP00000347184
Drugbank ID BE0008920
PharmGKB ID PA164741646
Target gene [HTT] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
4000299 chr4 124 166 281 571 View
4005953 chr4 6 12 10 28 View
4007680 chr4 10 8 18 View
4009578 chr4 11 11 View
4010432 chr4 6 2 1 9 View
4011255 chr4 7 7 View
4100032 chr4 85 12 15 112 View
4300089 chr4 31 2 33 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE17372 (GEO) AIDS-associated lymphoma 17 AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO) HIV-infected disease 44 HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372

HeatMap of cell type fractions in all samples Lollipop of HTT expression and immune infiltrating cell level correlation result in HIV+ samples
HTT expression: Low -> High

> Dataset: GSE50834

HeatMap of cell type fractions in all samples Lollipop of HTT expression and immune infiltrating cell level correlation result in HIV+ samples
HTT expression: Low -> High

Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).