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HTLV1 Target gene Detail Information

> HTR3C Gene Search Result


Gene Information
Gene Name HTR3C
Gene ID 170572
Gene Full Name 5-hydroxytryptamine receptor 3C
Transcripts ENSG00000178084
Virus HTLV1
Gene Type protein coding
HPA Location Info
Membrane Info Predicted membrane proteins
HPA Protein Class Info FDA approved drug targets, Predicted membrane proteins
Uniport_ID Q8WXA8
HGNC ID HGNC:24003
VEGA ID OTTHUMG00000156862
OMIM ID 610121
String ID 9606.ENSP00000322617
Drugbank ID BE0004818; BE0009584
PharmGKB ID PA134925741
Target gene [HTR3C] related to VISs
DVID Chromosome HM TFBS CA Sum of Overlapped Records Detail
6012538 chr3 20 2 22 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
GSE55851 (GEO) Adult T-cell leukemia 21 Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO) HTLV-1 associated myelopathy 39 Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO) HTLV-1 associated myelopathy 35 Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851

HeatMap of cell type fractions in all samples Lollipop of HTR3C expression and immune infiltrating cell level correlation result in HTLV1+ samples
HTR3C expression: Low -> High

> Dataset: GSE29312

HeatMap of cell type fractions in all samples Lollipop of HTR3C expression and immune infiltrating cell level correlation result in HTLV1+ samples
HTR3C expression: Low -> High

> Dataset: GSE29332

HeatMap of cell type fractions in all samples Lollipop of HTR3C expression and immune infiltrating cell level correlation result in HTLV1+ samples
HTR3C expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).