HTLV1 Target gene Detail Information

> HSPG2 Gene Search Result

Gene Information

Gene Name	HSPG2
Gene ID	3339
Gene Full Name	heparan sulfate proteoglycan 2
Gene Alias	PLC; SJA; SJS; HSPG; SJS1; PRCAN
Transcripts	ENSG00000142798
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Cytosol;Nucleoplasm;Plasma membrane;Predicted to be secreted;
HPA Protein Class Info	Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Uniport_ID	P98160
HGNC ID	HGNC:5273
VEGA ID	OTTHUMG00000002674
OMIM ID	142461
String ID	9606.ENSP00000363827
Drugbank ID	BE0001031
PharmGKB ID	PA29537

Target gene [HSPG2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6003656	chr1	36	39	72	147	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of HSPG2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
HSPG2 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of HSPG2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
HSPG2 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of HSPG2 expression and immune infiltrating cell level correlation result in HTLV1+ samples
HSPG2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).