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HBV Target gene Detail Information

> HSPA5 Gene Search Result


Gene Information
Gene Name HSPA5
Gene ID 3309
Gene Full Name heat shock protein family A (Hsp70) member 5
Gene Alias BIP; MIF2; GRP78; HEL-S-89n
Transcripts ENSG00000044574
Virus HBV
Gene Type protein coding
HPA Location Info Cytosol;
HPA Protein Class Info Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters
Gene Function Oncogene
Uniport_ID P11021
HGNC ID HGNC:5238
VEGA ID OTTHUMG00000020672
OMIM ID 138120
String ID 9606.ENSP00000324173
Drugbank ID BE0001098
PharmGKB ID PA29504
Target gene [HSPA5] related to virus gene/protein/region
ID PMID Mutation Gene/Protein/Region Description Detail
1 16227269 L77R
S
C
 View
2 27144395 M204V
RT
D
 View
3 26567840 A181T
RT
 View

Relationship between gene expression and immune infiltrating cell level
Data ID Disease Sample number Sample type
LIHC (TCGA) Liver hepatocellular carcinoma 424 Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC

HeatMap of cell type fractions in all samples Lollipop of HSPA5 expression and immune infiltrating cell level correlation result in HBV+ samples
HSPA5 expression: Low -> High
Contents
Description

Gene Information Note

  • Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

  • Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
  • Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).