HTLV1 Target gene Detail Information

> HRH3 Gene Search Result

Gene Information

Gene Name	HRH3
Gene ID	11255
Gene Full Name	histamine receptor H3
Gene Alias	HH3R; GPCR97
Transcripts	ENSG00000101180
Virus	HTLV1
Gene Type	protein coding
HPA Location Info
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins
Uniport_ID	Q9Y5N1
HGNC ID	HGNC:5184
VEGA ID	OTTHUMG00000032899
OMIM ID	604525
String ID	9606.ENSP00000342560
Drugbank ID	BE0000968
PharmGKB ID	PA29458

Target gene [HRH3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6009111	chr20	18	20	1	39	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of HRH3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
HRH3 expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of HRH3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
HRH3 expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of HRH3 expression and immune infiltrating cell level correlation result in HTLV1+ samples
HRH3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).