HBV Target gene Detail Information

> HRG Gene Search Result

Gene Information

Gene Name	HRG
Gene ID	3273
Gene Full Name	histidine rich glycoprotein
Gene Alias	HPRG; HRGP; THPH11
Transcripts	ENSG00000113905
Virus	HBV
Gene Type	protein coding
HPA Location Info
HPA Protein Class Info	Disease related genes, Plasma proteins, Predicted secreted proteins
Gene Function	Suppressor gene
Uniport_ID	P04196
HGNC ID	HGNC:5181
VEGA ID	OTTHUMG00000156578
OMIM ID	142640
String ID	9606.ENSP00000232003
Drugbank ID	BE0010257; BE0009910
PharmGKB ID	PA29455

Target gene [HRG] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1010843	chr3	11			11	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE114783 (GEO)	Chronic HBV (CHB) infection	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Hepatocellular carcinoma	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
GSE114783 (GEO)	Liver cirrhosis	36	Chronic hepatitis B patients (HBV+)(10),Hepatocellular carcinoma (HBV+)(10),Liver cirrhosis(HBV+)(10),Normal(3),HBV carriers (3)
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: GSE114783
HeatMap of cell type fractions in all samples	Lollipop of HRG expression and immune infiltrating cell level correlation result in HBV+ Chronic HBV (CHB) infection samples
HRG expression: Low -> High
Lollipop of HRG expression and immune infiltrating cell level correlation result in HBV+ Liver cirrhosis samples	Lollipop of HRG expression and immune infiltrating cell level correlation result in HBV+ Hepatocellular carcinoma samples


> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of HRG expression and immune infiltrating cell level correlation result in HBV+ samples
HRG expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).