HTLV1 Target gene Detail Information

> HR Gene Search Result

Gene Information

Gene Name	HR
Gene ID	55806
Gene Full Name	HR, lysine demethylase and nuclear receptor corepressor
Gene Alias	AU; MUHH; ALUNC; HYPT4; MUHH1; HSA277165
Transcripts	ENSG00000168453
Virus	HTLV1
Gene Type	protein coding
HPA Location Info	Nucleoplasm;
HPA Protein Class Info	Disease related genes, Predicted intracellular proteins
Uniport_ID	O43593
HGNC ID	HGNC:5172
VEGA ID	OTTHUMG00000097089
OMIM ID	602302
String ID	9606.ENSP00000370826
PharmGKB ID	PA29443

Target gene [HR] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
6002497	chr14	236	1		237	View
6009574	chr5	31	4	1	36	View
6009575	chr5	31	4	1	36	View
6010923	chr5	26	2		28	View
6015408	chr8	12	2		14	View
6017140	chr14	8	3		11	View
6024325	chr5	3			3	View
6031363	chr14				0	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE55851 (GEO)	Adult T-cell leukemia	21	Normal (3), Asymptomatic carriers (HTLV1+)(6), Adult T-cell Leukemia-lymphoma (HTLV1+)(12)
GSE29312 (GEO)	HTLV-1 associated myelopathy	39	Normal (9), Asymptomatic carriers (HTLV1+)(20), HTLV-1-associated myelopathy (HTLV1+)(10)
GSE29332 (GEO)	HTLV-1 associated myelopathy	35	Normal (8), Asymptomatic carriers (HTLV1+)(17), HTLV-1-associated myelopathy (HTLV1+)(10)

> Dataset: GSE55851
HeatMap of cell type fractions in all samples	Lollipop of HR expression and immune infiltrating cell level correlation result in HTLV1+ samples
HR expression: Low -> High

> Dataset: GSE29312
HeatMap of cell type fractions in all samples	Lollipop of HR expression and immune infiltrating cell level correlation result in HTLV1+ samples
HR expression: Low -> High

> Dataset: GSE29332
HeatMap of cell type fractions in all samples	Lollipop of HR expression and immune infiltrating cell level correlation result in HTLV1+ samples
HR expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).