HIV Target gene Detail Information

> HPS3 Gene Search Result

Gene Information

Gene Name	HPS3
Gene ID	84343
Gene Full Name	HPS3, biogenesis of lysosomal organelles complex 2 subunit 1
Gene Alias	SUTAL; BLOC2S1
Transcripts	ENSG00000163755
Virus	HIV
Gene Type	protein coding
HPA Location Info	Golgi apparatus;Plasma membrane;
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	Q969F9
HGNC ID	HGNC:15597
VEGA ID	OTTHUMG00000159548
OMIM ID	606118
String ID	9606.ENSP00000296051
PharmGKB ID	PA29433

Target gene [HPS3] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000207	chr3	625	66	50	741	View
4015385	chr3		1		1	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of HPS3 expression and immune infiltrating cell level correlation result in HIV+ samples
HPS3 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of HPS3 expression and immune infiltrating cell level correlation result in HIV+ samples
HPS3 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).