HBV Target gene Detail Information

> HMGCS2 Gene Search Result

Gene Information

Gene Name	HMGCS2
Gene ID	3158
Gene Full Name	3-hydroxy-3-methylglutaryl-CoA synthase 2
Transcripts	ENSG00000134240
Virus	HBV
Gene Type	protein coding
HPA Location Info	Mitochondria;
HPA Protein Class Info	Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Uniport_ID	P54868
HGNC ID	HGNC:5008
VEGA ID	OTTHUMG00000012101
OMIM ID	600234
String ID	9606.ENSP00000358414
PharmGKB ID	PA29338

Target gene [HMGCS2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1005302	chr1	49	7	1	57	View
1005566	chr1	24	28		52	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of HMGCS2 expression and immune infiltrating cell level correlation result in HBV+ samples
HMGCS2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).