HIV Target gene Detail Information

> HLCS Gene Search Result

Gene Information

Gene Name	HLCS
Gene ID	3141
Gene Full Name	holocarboxylase synthetase
Gene Alias	HCS
Transcripts	ENSG00000159267
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;
HPA Protein Class Info	Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins
Uniport_ID	P50747
HGNC ID	HGNC:4976
VEGA ID	OTTHUMG00000086636
OMIM ID	609018
String ID	9606.ENSP00000382071
Drugbank ID	BE0000159
PharmGKB ID	PA29310

Target gene [HLCS] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4014441	chr21		2		2	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of HLCS expression and immune infiltrating cell level correlation result in HIV+ samples
HLCS expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of HLCS expression and immune infiltrating cell level correlation result in HIV+ samples
HLCS expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).