HBV Target gene Detail Information

> HLA-B Gene Search Result

Gene Information

Gene Name	HLA-B
Gene ID	3106
Gene Full Name	major histocompatibility complex, class I, B
Gene Alias	AS; HLAB; B-4901
Transcripts	ENSG00000206450
Virus	HBV
Gene Type	protein coding
HPA Location Info
Membrane Info	Predicted membrane proteins
HPA Protein Class Info	Cancer-related genes, Predicted intracellular proteins, Predicted membrane proteins
Uniport_ID	P01889; P30480; P30486; Q29836; Q31610; Q31612
HGNC ID	HGNC:4932
VEGA ID	OTTHUMG00000149955
OMIM ID	142830
String ID	9606.ENSP00000399168
Drugbank ID	BE0004082
PharmGKB ID	PA35056
FDA Approved Drug	Abacavir;Carbamazepine;Fosphenytoin;Oxcarbazepine;Pazopanib;Phenytoin

Target gene [HLA-B] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
1000253	chr6	2971	378	200	3549	View
1002648	chr6	207	22	2	231	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
LIHC (TCGA)	Liver hepatocellular carcinoma	424	Liver hepatocellular carcinoma HCV (HBV+)(86), Liver hepatocellular carcinoma HCV (HBV-)(19), Liver hepatocellular carcinoma (HBV+)(209), Liver hepatocellular carcinoma (HBV+)(60), Paracancerous HCV (HBV+)(4), Paracancerous (HBV-)(28), Paracancerous (HBV+)(18)

> Dataset: LIHC
HeatMap of cell type fractions in all samples	Lollipop of HLA-B expression and immune infiltrating cell level correlation result in HBV+ samples
HLA-B expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).