HIV Target gene Detail Information

> HK2 Gene Search Result

Gene Information

Gene Name	HK2
Gene ID	3099
Gene Full Name	hexokinase 2
Gene Alias	HKII; HXK2
Transcripts	ENSG00000159399
Virus	HIV
Gene Type	protein coding
HPA Location Info	Cytosol;Mitochondria;Centrosome;Vesicles;
HPA Protein Class Info	Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins
Uniport_ID	P52789
HGNC ID	HGNC:4923
VEGA ID	OTTHUMG00000129972
OMIM ID	601125
String ID	9606.ENSP00000290573
PharmGKB ID	PA29301

Target gene [HK2] related to VISs

DVID	Chromosome	HM	TFBS	CA	Sum of Overlapped Records	Detail
4000040	chr2	234	1172	395	1801	View
4011838	chr19	6			6	View

Relationship between gene expression and immune infiltrating cell level

Data ID	Disease	Sample number	Sample type
GSE17372 (GEO)	AIDS-associated lymphoma	17	AIDS-Related Lymphomas (HIV+)(17)
GSE50834 (GEO)	HIV-infected disease	44	HIV infected (23), HIV/TB co-infected (21)

> Dataset: GSE17372
HeatMap of cell type fractions in all samples	Lollipop of HK2 expression and immune infiltrating cell level correlation result in HIV+ samples
HK2 expression: Low -> High

> Dataset: GSE50834
HeatMap of cell type fractions in all samples	Lollipop of HK2 expression and immune infiltrating cell level correlation result in HIV+ samples
HK2 expression: Low -> High

Contents
Description

Gene Information Note

Integration Table: if previous studies reported that target gene was altered by virus integration events, the overlap between VISs in this literature and Cistrome factors was listed in the "Target gene [gene] related to VIS" section

Immune Analysis Plot Note

Left: Heatmap of target gene expression and the level of various types of immune cells (cell type fractions) in all samples based on CIBERSORT method.
Right: Correlation of target gene expression and the level of various types of immune cells in virus positive samples (Pearson Correlation Coefficient).